An RNA triple helix consists of three strands A Watson–Crick RNA double helix whose majorgroove establishes hydrogen bonds with the socalled "third strand"In the past 15 years, it has been recognized that these majorgroove RNA triple helices, like singlestranded and doublestranded RNA, also mediate prominent biological rolesThe specialized ribonuclease Dicer initiates RNA interference by cleaving doublestranded RNA (dsRNA) substrates into small fragments about 25 nucleotides in length InExamples include the packaging of dsRNA viral genomes into capsids, deformations of the ribosome during translation (1, 2), and more generally conformational changes of functional RNAs while folding or due to interactions with proteins (3, 4)
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